Thy-1 in Integrin Mediated Mechanotransduction
نویسندگان
چکیده
منابع مشابه
Integrin-mediated mechanotransduction
Cells can detect and react to the biophysical properties of the extracellular environment through integrin-based adhesion sites and adapt to the extracellular milieu in a process called mechanotransduction. At these adhesion sites, integrins connect the extracellular matrix (ECM) with the F-actin cytoskeleton and transduce mechanical forces generated by the actin retrograde flow and myosin II t...
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Progressive fibrosis is characterized by excessive deposition of extracellular matrix (ECM), resulting in gross alterations in tissue mechanics. Changes in tissue mechanics can further augment scar deposition through fibroblast mechanotransduction. In idiopathic pulmonary fibrosis, a fatal form of progressive lung fibrosis, previous work has shown that loss of Thy-1 (CD90) expression in fibrobl...
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Changes in tissue and organ stiffness occur during development and are frequently symptoms of disease. Many cell types respond to the stiffness of substrates and neighboring cells in vitro and most cell types increase adherent area on stiffer substrates that are coated with ligands for integrins or cadherins. In vivo cells engage their extracellular matrix (ECM) by multiple mechanosensitive adh...
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In Focus • THE JOURNAL OF CELL BIOLOGY Integrins are transmembrane receptors that help link the extracellular matrix (ECM) to the cytoskeleton. They’re essential for cell–substrate and cell–cell adhesion, cell locomotion, and for sensing and responding to the extracellular environment (1). Injury or pathological conditions such as cancer can alter the extracellular environment. For example, lun...
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ژورنال
عنوان ژورنال: Frontiers in Cell and Developmental Biology
سال: 2019
ISSN: 2296-634X
DOI: 10.3389/fcell.2019.00022